10 Best Melatonin Supplements for Dogs in 2025 – Reviews & Top Picks

Like humans, dogs can struggle with anxiety and often have issues getting a good night’s sleep. Veterinarians offer prescription medications for canines with severe conditions, but you can also find over-the-counter products that can help calm your dog. Several manufacturers produce melatonin supplements, but which is best for your pet?

We examined the best melatonin supplements on the market and compiled a list of detailed reviews to help you decide which brand is ideal for your furry friend.

A Quick Comparison of Our Favorites in 2025

Rating	Image	Product	Details
Best Overall		Zesty Paws Advanced Calming Bites	No artificial flavors or colors Grain-free Ingredients helps relaxation	CHECK PRICE
Best Value		waggedy Calm Stress	Inexpensive No corn or soy in formula Help support calmness	CHECK PRICE
Premium Choice		Pet Wellbeing Pet Melatonin	3mg of melatonin Only four natural ingredients No GMOs or preservatives	CHECK PRICE
Best for Puppies		Nature’s Synergy Hemp Oil	Made of hemp oil and melatonin Eco-friendly sourced ingredients Made in an FDA-registered facility	CHECK PRICE
		ThunderWunders Melatonin	Wheat-free No artificial flavors or colors Includes ginger to treat sensitive stomachs	CHECK PRICE

The 10 Best Melatonin Supplements for Dogs

1. Zesty Paws Advanced Calming Bites — Best Overall

Zesty Paws Advanced Calming Bites are designed to combat everyday stress, hyperactivity, and nervousness in canines, making these the best overall melatonin supplements for dogs. The chewy treats contain no artificial flavors, colors, or preservatives, and they’re safe for daily use. Like many competitors, Zesty Paws includes additional natural ingredients to support calmness. Chamomile, valerian root, Sensoril ashwagandha, and l-tryptophan benefit pets that do not seem affected by supplements containing only melatonin.

The grain-free formula is ideal for pups with gluten sensitivities, and the natural turkey flavor is a hit with picky canines. Supplements and medications can be problematic when dogs dislike the taste, but most pups are happy to eat Zesty Paws before a trip to the vet or a stressful event like a fireworks display.

Some customers have mentioned that their pets are unaffected by this product.

2. waggedy Calm Stress & Anxiety Relief Melatonin Dog Supplement — Best Value

The waggedy Calm Stress & Anxiety Relief Melatonin Dog Supplement is an excellent choice if you want to try giving your dog calming supplements without overspending. Supplements can be expensive, especially when you have multiple pets, but waggedy makes the best melatonin supplement for dogs for the money. It contains chamomile, thiamine mononitrate, passion flower, and melatonin to calm your pet during stressful events. It does not include corn, soy, or unnecessary fillers. waggedy Calm Stress is safe for dogs at least 1 year old, and the tasty savory flavor makes your pet believe that they’re getting a treat rather than a supplement.

Customers are happy with the product’s effect on their stressed-out pets, but some have mentioned that the supplements work better for reducing stress than helping with sleep.

3. Pet Wellbeing Pet Melatonin Bacon Flavored Liquid — Premium Choice

A chewable treat is the most common form of melatonin for dogs, but some dogs dislike the flavor of supplements and cannot handle tablets. Pet Wellbeing Pet Melatonin Bacon Flavored Liquid is an excellent alternative to using chews, and dogs seem to like the bacon flavoring. Unlike most supplements, Pet Wellbeing only contains deionized water, natural bacon flavor, vegetable glycerin, and animal-derived melatonin. The manufacturer claims that the liquid treats sleeplessness and anxiety and promotes healthy urination and appetite.

The drops are more expensive than many competitors, but they contain more melatonin (3 mg) and fewer unnecessary ingredients. Most supplements list melatonin as a minor or inactive ingredient, but Pet Wellbeing’s drops list it as the only active component. With a higher melatonin content, the liquid seems to help with sleep more than other products.

4. Nature’s Synergy Hemp Oil & Melatonin for Dogs — Best for Puppies

Selecting a safe supplement for your puppy can be challenging. Some dogs are too young for soft chews due to the choking hazard, but you can use Nature’s Synergy Hemp Oil & Melatonin for Dogs for your little friend. The liquid is produced in an FDA-registered facility, and its only two ingredients are hemp oil and melatonin. Hemp oil contains omega-3, omega-6, and omega-9 fatty acids to fight inflammation and soothe aching joints.

Unlike its competitors, Nature’s Synergy does not include additional savory flavors to make it more appealing. While some dogs did not like the hemp oil’s flavor, others were unaware when it was added to their food. Nature’s Synergy recommends adding a small quantity to wet food and slowly increasing the dosage until you reach the desired amount. Puppies only need half of a dropper every 12 hours.

5. ThunderWunders Melatonin Calming Dog Chews

Fireworks displays, thunderstorms, and other loud noises can raise anxiety levels in dogs, but ThunderWunders Melatonin Calming Dog Chews are designed to relax your pet. The wheat-free formula contains passionflower, thiamine, and l-tryptophan to calm your dog and melatonin to help regulate sleep. Stress can disrupt your dog’s appetite, and ThunderWunders includes ginger in its recipe to help settle an uneasy stomach. It’s safe for all breeds that are at least 12 weeks old.

Most customers with nervous or aging pets are happy with ThunderWunders, but some have mentioned that the supplement does not affect their pets. Compared to some other brands, it does have less melatonin.

6. PetHonesty Calming Hemp+ Max-Strength Duck Flavored Soft Chews

PetHonesty Calming Hemp+ Max-Strength Duck Flavored Soft Chews use an all-natural recipe that does not contain wheat, soy, GMOs, or chemical preservatives. The formula contains hemp, melatonin, chamomile, valerian root, and Suntheanine to help your pet when environmental stresses take a toll on their mental health. Some melatonin supplements take several hours or days to work, but PetHonesty Chews only take 30 to 45 minutes. The chews are safe for dogs of all ages, but dogs under 25 pounds only require half of a chew.

Dogs seem to like these duck-flavored chews, and most owners are satisfied with the product, but it does not calm all dogs.

7. Lignans for Life 6 mg Melatonin

Lignans for Life 6 mg Melatonin is the only product on this list that is safe for dogs and humans. It’s composed of melatonin, vegetable cellulose, microcrystalline cellulose, and magnesium stearate. Since it’s made for multiple species, Lignans does not have a savory flavor that appeals to canines. Also, rather than a chewy treat, it’s a tablet that must be hidden in a pill pocket or crushed and added to food. Lignans for Life contains the highest dosage of melatonin of any product on this list, so we suggest using the tablets only on dogs with severe anxiety and difficulty sleeping.

Customers are happy with the powerful supplement, but some are concerned that it’s not designed for daily use.

8. Zesty Paws Hemp Elements Calming OraStix

Zesty Paws Hemp Elements Calming OraStix are designed to calm your nervous pup and support healthy teeth. The grain-free recipe includes Suntheanine, melatonin, valerian root, chamomile, and magnesium citrate to relax your pet. Zesty Paws includes peppermint oil, kelp, and rosemary extract to support healthy teeth and gums. The sticks are safe for dogs of all ages, and the recipe contains no artificial flavors or colors. They’re the only product on this list that uses dental sticks rather than chews or liquid, and most dog owners seem pleased with the results.

However, the dosage requirements for large dogs might be too much: If your dog weighs over 75 pounds, the recommended dosage is three sticks. Also, some customers have reported that Zesty Paws does not affect their pets.

9. Dr. Oscar Dog Sleep Aid

While most melatonin products for dogs focus more on treating anxiety than sleeplessness, Dr. Oscar Dog Sleep Aid is specifically designed to improve your dog’s sleeping habits. It contains lemon balm, ashwagandha, valerian root, and passion flower to treat agitation and relies on 3 mg of melatonin to help with sleep. The manufacturer also claims that melatonin supports hair growth and can help treat pattern baldness and alopecia.

However, Dr. Oscar’s pills are not designed to keep animals calm during stressful events, and they can take a long time to work. The biggest concern is the consistency of the product’s color. Some customers receive brown pills with one order and white ones with the next.

10. NaturVet Senior Advanced Calming Aid With Non-GMO Ingredients Dog Supplement

If you have a mature dog that scares easily and suffers from nervousness, you can try NaturVet Senior Advanced Calming Aid With Non-GMO Ingredients Dog Supplement. The soft chews are designed for aging teeth, and the chamomile, thiamine, passion flower, l-tryptophan, and melatonin in the recipe help nervous dogs remain calm in stressful situations. NaturVet chews are made with non-GMO ingredients and are safe for everyday use.

Although the chews have beneficial components, they also contain unnecessary fat and starches, such as canola oil and dried potato. The product’s biggest drawback is the flavor; several dogs cannot benefit from the calming effects because they dislike the taste.

Buyer’s Guide: How to Find the Best Melatonin Supplements for Dogs

Dog owners have had success with melatonin as a sleep aid and anxiety reliever, but which product is right for your pet? Let’s look at some of the factors that may influence your decision.

Veterinary Advice

We reviewed over-the-counter products, but you can also request prescription medication if your pet requires a pure dosage of melatonin. Each commercial melatonin product has a note with the nutritional information that recommends visiting a veterinarian before administering the hormone to your dog. Due to the expense, though, many consumers purchase melatonin online without seeing a doctor.

Although the products are safe and produced in FDA-registered facilities, some brands contain additional substances that may be foreign to your pet’s diet. Checking with your vet first can prevent an adverse reaction to a previously unknown allergy. Your vet spends less time with your pet than you, but they know more about how a drug reacts with a canine’s body.

Melatonin Dosage

Each manufacturer seems to use a different quantity of melatonin in its products, and some of the marketing language on the product’s label and website can obscure the facts. The word “melatonin” is usually highlighted on every calming chew, liquid, and tablet, but sometimes, melatonin is an inactive ingredient with a tiny amount measured in micrograms.

The highest dosage on this list is 7 mg, and the lowest is 20 mcg. Most vets prescribe dosages of 1.5 mg to small dogs under 25 pounds, 3 mg to medium dogs under 99 pounds, and 6 mg to dogs over 100 pounds. Since several commercial brands contain additional herbs and natural components, it may be challenging to determine which substance is helping your pup. However, the quantity of melatonin is less critical if the supplement helps your dog relax and sleep without interruption.

Active and Inactive Ingredients

Pet parents have had success with melatonin products that use the hormone as an active and inactive ingredient, but if your doctor recommends a melatonin regimen for your pet, look for brands that list melatonin as the active ingredient. Otherwise, the supplement may only contain a trace of the hormone, which is unlikely to have a profound effect on your pet’s behavior.

Milligrams vs. Micrograms

When you’re examining the supplement’s ingredients list, pay close attention to the units of measurement used. 500 micrograms (mcg) may sound like a lot, but it’s only 0.5 milligrams (mg). Although some manufacturers may seem like they’re being too stingy with the melatonin, it is safer, legally and morally, to use a hormone sparingly until more testing has confirmed its effectiveness as a safe treatment for all breeds and ages.

Our Best Melatonin Supplements for Dogs Selection Process

The melatonin supplements we reviewed in this article were chosen by PangoVet’s writers and editors, in collaboration with our experienced veterinary team, based on personal experience with the product, knowledge and expertise about the pet’s care needs, brand reputation, and reviews across multiple retail outlets from other customers that have purchased and used the product. The combination of these factors allows us to gather a wide range of information to help you choose only the best melatonin supplements and ensure you have the most accurate information about these products to promote proper care, health, and well-being of your beloved pets.

Why Trust PangoVet?

PangoVet’s licensed and experienced veterinarians have a knowledge base that extends to all kinds of pets—furry, scaly, and feathered—and want only the best for pets of all shapes and sizes. We also have experienced writers and editors who are pet owners with a variety of different pets, and we love our pets as much as you do. We recognize pets as part of our family. We make sure to only choose products from reputable brands highly rated by customers as well as products that we have personal experience with, to ensure that every melatonin supplements featured in this review is high-quality and safe for your pets.

Conclusion

Melatonin has helped many canines with anxiety and insomnia, so we hope that you and your furry friend will have success with one of the products from these reviews. Our top pick is Zesty Paws Advanced Calming Bites, as this is one of the few brands that appealed to dogs’ taste buds and helped calm their behavior, and the grain-free formula is safer for dogs with allergies. Our premium choice is Pet Wellbeing Pet Melatonin Bacon Flavored Liquid. Although this one is a bit pricey, many dog owners are pleased with the results.

Featured Image Credit: pixexid, Pixabay